Área Metabolismo

Grupo de Investigación en Bioquímica Tisular

Juan R. Viña

El Dr. Juan R. Viña, Director General de la Fundación INCLIVA desde su creación en 1991 hasta 2012, es Catedrático del Departamento de Bioquímica y Biología Molecular de la Facultad de Medicina de la Universitat de València, donde también completó sus estudios de licenciatura y doctorado.

Ha trabajado en el Metabolic Research Laboratory, Nuffield Department of Clinical Medicine, Radcliffe Infirmary de la Universidad de Oxford (Reino Unido) durante un año y medio. Así mismo, trabajó durante dos años en el Hershey Medical Center del Pennsylvania State University y actualmente es Research Professor del Department Physiology and Biophysics.  The Chicago Medical School de Estados Unidos. 

 

Grupo de Investigación en Bioquímica Tisular

Técnico

Concha García de Mier

Investigador colaborador

Elena Ruiz García-Trevijano
Eva Serna García
Luis Torres Asensi
Teresa Barber Ballester
Vicente Miralles Fernández

Investigador predoctoral

Lucía Rodríguez Fernández

Determinación de los mecanismos que regulan la involución de la glándula mamaria tras la lactancia. Estudio de las calpaínas en el control de la muerte celular programada y la remodelación tisular que acontecen en el tejido mamario tras el destete. Tras su activación estas calpaínas se traslocan a diferentes compartimentos (membrana plasmática, mitocondria, núcleos, lisosomas, etc), donde ejerce su acción degradando proteínas diana.

Estudiar mediante ChIP-chip el papel de Id2 y E2F4 sobre los mecanismos epigenéticos de control de la expresión génica en hígado. E2F4 e Id2 se influyen mutuamente en la posición de unión al DNA y se comportan como un complejo que, junto con la RNApol II se encuentra sobre determinados genes, de modo que dichos genes estarían “sensibilizados” frente a determinados estímulos.

Número total de publicaciones: 35. Factor de Impacto acumulado: 138.81
Erratum to: "EPICO 3.0. Recommendations on invasive candidiasis in patients with complicated intra-abdominal infection and surgical patients with ICU extended stay" [Rev Iberoam Micol. 33 (4) (2016) 196-205].
Maseda E, Rodríguez AH, Aguilar G, Pemán J, Zaragoza R, Ferrer R, Llinares P, Grau S, EPICO Project Group.
Revista iberoamericana de micología. 2017 Jan - Mar. 61. FI: 1.33
Jávea consensus guidelines for the treatment of Candida peritonitis and other intra-abdominal fungal infections in non-neutropenic critically ill adult patients.
Pemán J, Aguilar G, Valía JC, Salavert M, Navarro D, Zaragoza R, Jávea Intra-Abdominal Fungal Infection Group.
Revista iberoamericana de micología. 2017 Jul - Sep. 130-142. FI: 1.33
Epidemiology and prognosis of candidaemia in elderly patients
Ramos-Martínez A, Vicente-López N, Sánchez-Romero I, Padilla B, Merino-Amador P, Garnacho-Montero J, Ruiz-Camps I, Montejo M, Salavert M, Mensa J, Cuenca-Estrella M; Members of the CANDIPOP Project from GEIH-GEMICOMED (SEIMC) and REIPI.
Mycoses. 2017 Aug 23. 0933-7407. FI: 2.252
Isoform-specific function of calpains in cell adhesion disruption: studies in postlactational mammary gland and breast cancer.
Rodríguez-Fernández L, Ferrer-Vicens I, García C, Oltra SS, Zaragozá R, Viña JR, García-Trevijano ER
The Biochemical journal.. 2016 Sep 15. 2893-909. FI: 3.562
Human exceptional longevity: transcriptome from centenarians is distinct from septuagenarians and reveals a role of Bcl-xL in successful aging.
Borras C, Abdelaziz KM, Gambini J, Serna E, Inglés M, de la Fuente M, Garcia I, Matheu A, Sanchís P, Belenguer A, Errigo A, Avellana JA, Barettino A, Lloret-Fernández C, Flames N, Pes G, Rodriguez-Mañas L, Viña J
Aging. 2016 Oct 28. 3185-3208. FI: 3.979
Sepsis in preterm infants causes alterations in mucosal gene expression and microbiota profiles compared to non-septic twins.
Cernada M, Bäuerl C, Serna E, Collado MC, Martínez GP, Vento M
Scientific reports.. 2016 May 16. 25497. FI: 5.578
Biotin-Genomic Run-On (Bio-GRO): A High-Resolution Method for the Analysis of Nascent Transcription in Yeast.
Jordán-Pla A, Miguel A, Serna E, Pelechano V, Pérez-Ortín JE
Photosynthesis research protocols. 2016. 125-39
Dysfunctional mitochondrial fission impairs cell reprogramming.
Prieto J, León M, Ponsoda X, García-García F, Bort R, Serna E, Barneo-Muñoz M, Palau F, Dopazo J, López-García C, Torres J
Cell cycle.. 2016 Oct 18. 0. FI: 3.952
How Glutamate Is Managed by the Blood-Brain Barrier.
Hawkins RA, Viña JR
Biology. 2016 Oct 8.
Procalcitonin (PCT) levels for ruling-out bacterial coinfection in ICU patients with influenza: A CHAID decision-tree analysis.
Rodríguez AH, Avilés-Jurado FX, Díaz E, Schuetz P, Trefler SI, Solé-Violán J, Cordero L, Vidaur L, Estella Á, Pozo Laderas JC, Socias L, Vergara JC, Zaragoza R, Bonastre J, Guerrero JE, Suberviola B, Cilloniz C, Restrepo MI, Martín-Loeches I, SEMICYUC/GETGAG Working Group
The Journal of infection.. 2016 Feb. 143-51. FI: 4.441
EGF-Induced Acetylation of Heterogeneous Nuclear Ribonucleoproteins Is Dependent on KRAS Mutational Status in Colorectal Cancer Cells.
Roda D, Castillo J, Telechea-Fernández M, Gil A, López-Rodas G, Franco L, González-Rodríguez P, Roselló S, Pérez-Fidalgo JA, García-Trevijano ER, Cervantes A, Zaragozá R
PloS one. 2015. e0130543. FI: 3.234
Involvement of Different networks in mammary gland involution after the pregnancy/lactation cycle: Implications in breast cancer.
Zaragozá R, García-Trevijano ER, Lluch A, Ribas G, Viña JR
IUBMB life.. 2015 Apr. 227-38. FI: 3.143
MicroRNA Profile in Response to Doxorubicin Treatment in Breast Cancer.
Tormo E, Pineda B, Serna E, Guijarro A, Ribas G, Fores J, Chirivella E, Climent J, Lluch A, Eroles P
Journal of Cellular Biochemistry. 2015 Sep. 2061-73. FI: 3.446
Differential functions of calpain 1 during epithelial cell death and adipocyte differentiation in mammary gland involution.
Arnandis T, Ferrer-Vicens I, Torres L, García C, Garcia-Trevijano ER, Zaragoza R, Viña JR
The Biochemical journal. 2014 Apr 15. 355-68. FI: 4.396
Gene expression profile induced by ovariectomy in bone marrow of mice: A functional approach to identify new candidate genes associated to osteoporosis risk in women.
Pineda B, Serna E, Laguna-Fernández A, Noguera I, Panach L, Hermenegildo C, Tarín JJ, Cano A, García-Pérez MÁ
Bone. 2014 Aug. 33-41. FI: 4.461
Epidemiology and predictive factors for early and late mortality in Candida bloodstream infections: a population-based surveillance in Spain.
Puig-Asensio M, Padilla B, Garnacho-Montero J, Zaragoza O, Aguado JM, Zaragoza R, Montejo M, Muñoz P, Ruiz-Camps I, Cuenca-Estrella M, Almirante B, CANDIPOP Project, GEIH-GEMICOMED (SEIMC), REIPI
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases. 2014 Apr. O245-54. FI: 5.197
Correlation between EGFR amplification and the expression of microRNA-200c in primary glioblastoma multiforme.
Serna E, Lopez-Gines C, Monleon D, Muñoz-Hidalgo L, Callaghan RC, Gil-Benso R, Martinetto H, Gregori-Romero A, Gonzalez-Darder J, Cerda-Nicolas M
PloS one. 2014. e102927. FI: 3.534
In vivo genome-wide binding of Id2 to E2F4 target genes as part of a reversible program in mice liver.
Ferrer-Vicens I, Riffo-Campos ÁL, Zaragozá R, García C, López-Rodas G, Viña JR, Torres L, García-Trevijano ER
Cellular and molecular life sciences : CMLS. 2014 Sep. 3583-97. FI: 5.808
Vitamin A Deficiency and Alterations in the Extracellular Matrix.
Barber T, Esteban-Pretel G, Marín MP, Timoneda J
Nutrients. 2014 Nov 10. 4984-5017. FI: 3.148
Response to long-term NaHCO3-derived alkalinity in model Lotus japonicus Ecotypes Gifu B-129 and Miyakojima MG-20: transcriptomic profiling and physiological characterization.
Babuin MF, Campestre MP, Rocco R, Bordenave CD, Escaray FJ, Antonelli C, Calzadilla P, Gárriz A, Serna E, Carrasco P, Ruiz OA, Menendez AB
PloS one. 2014. e97106. FI: 3.534
Genome-wide expression profiles in very low birth weight infants with neonatal sepsis.
Cernada M, Serna E, Bauerl C, Collado MC, Pérez-Martínez G, Vento M
Pediatrics. 2014 May. e1203-11. FI: 5.297
Clinical effects of viral relapse after interferon plus ribavirin in patients co-infected with human immunodeficiency virus and hepatitis C virus.
Berenguer J, Alvarez-Pellicer J, Carrero A, Von Wichmann MA, López-Aldeguer J, Mallolas J, Galindo MJ, Van Den Eynde E, Téllez MJ, Quereda C, Tural C, Sanz J, Barros C, Santos I, Pulido F, Guardiola JM, Ortega E, Rubio R, Jusdado JJ, Montes ML, Gaspar G, Barquilla E, Bellón JM, González-García J, GESIDA HIV/HCV Cohort Study Group
Journal of hepatology. 2013 Jun. 1104-12. FI: 9.858000000000001
Community-acquired Legionella Pneumonia in the intensive care unit: Impact on survival of combined antibiotic therapy.
Rello J, Gattarello S, Souto J, Sole-Violan J, Valles J, Peredo R, Zaragoza R, Vidaur L, Parra A, Roig J, Community-Acquired Pneumonia in Unidad de Cuidados Intensivos 2 CAPUCI 2 Study Investigators
Medicina intensiva / Sociedad Española de Medicina Intensiva y Unidades Coronarias. 2013 Jun-Jul. 320-6. FI: 1.323
2013: The «Seville» document on Consensus on the Alternatives to Allogenic Blood Transfusion.
Leal-Noval SR, Muñoz M, Asuero M, Contreras E, García-Erce JA, Llau JV, Moral V, Páramo JA, Quintana M
Farmacia hospitalaria : órgano oficial de expresión científica de la Sociedad Española de Farmacia Hospitalaria. 2013 Mayo-Junio. 209-235
Microvascular obstruction in the right ventricle in reperfused anterior myocardial infarction. Macroscopic and pathologic evidence in a swine model.
Bonanad C, Ruiz-Sauri A, Forteza MJ, Chaustre F, Minana G, Gomez C, Diaz A, Noguera I, de Dios E, Nunez J, Mainar L, Sanchis J, Morales JM, Monleon D, Chorro FJ, Bodi V
Thrombosis research. 2013 Nov. 592-8. FI: 3.133
Epigenetic biomarkers in laboratory diagnostics: emerging approaches and opportunities.
Sandoval J, Peiró-Chova L, Pallardó FV, García-Giménez JL
Expert review of molecular diagnostics. 2013 Jun. 457-71. FI: 4.27
Constitutive activation of JAK2 in mammary epithelium elevates Stat5 signalling, promotes alveologenesis and resistance to cell death, and contributes to tumourigenesis.
Caffarel MM, Zaragoza R, Pensa S, Li J, Green AR, Watson CJ
Cell death and differentiation. 2012 Mar. 511-22. FI: 8.371
Age-dependent changes in the transcription profile of long-lived Drosophila over-expressing glutamate cysteine ligase.
Radyuk SN, Gambini J, Borras C, Serna E, Klichko VI, Viña J, Orr WC
Mechanisms of ageing and development. 2012 Jun. 401-13. FI: 3.264
Calpains mediate epithelial-cell death during mammary gland involution: mitochondria and lysosomal destabilization.
Arnandis T, Ferrer-Vicens I, García-Trevijano ER, Miralles VJ, García C, Torres L, Viña JR, Zaragozá R
Cell death and differentiation. 2012 Sep. 1536-48. FI: 8.371
Evaluation of the quality of publications on randomized clinical trials using the consolidated standards of reporting trials (CONSORT) statement guidelines in a spanish tertiary hospital.
Dasí F, Navarro-García MM, Jiménez-Heredia M, Magraner J, Viña JR, Pallardó FV, Cervantes A, Morcillo E
Journal of clinical pharmacology. 2012 Jul. 1106-14. FI: 2.963
Evolution of tumour biology upon progression. Do we know our enemy?
Lluch A, Bosch A
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 2012 Jun. 399-400. FI: 1.276
Metabolomic profile of human myocardial ischemia by nuclear magnetic resonance spectroscopy of peripheral blood serum: a translational study based on transient coronary occlusion models.
Bodi V, Sanchis J, Morales JM, Marrachelli VG, Nunez J, Forteza MJ, Chaustre F, Gomez C, Mainar L, Minana G, Rumiz E, Husser O, Noguera I, Diaz A, Moratal D, Carratala A, Bosch X, Llacer A, Chorro FJ, Viña JR, Monleon D
Journal of the American College of Cardiology. 2012 May 1. 1629-41. FI: 14.086
Molecular biology in breast cancer: intrinsic subtypes and signaling pathways.
Eroles P, Bosch A, Pérez-Fidalgo JA, Lluch A
Cancer treatment reviews. 2012 Oct. 698-707. FI: 6.024
Centenarians, but not octogenarians, up-regulate the expression of microRNAs.
Serna E, Gambini J, Borras C, Mohammed K, Belenguer A, Sanchis P, Avellana JA, Rodriguez-Mañas L, Viña J
Scientific reports. 2012. 961. FI: 2.927
Recommendations of the Infectious Diseases Work Group (GTEI) of the Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC) and the Infections in Critically Ill Patients Study Group (GEIPC) of the Spanish Society of Infectiou
Rodríguez A, Alvarez-Rocha L, Sirvent JM, Zaragoza R, Nieto M, Arenzana A, Luque P, Socías L, Martín M, Navarro D, Camarena J, Lorente L, Trefler S, Vidaur L, Solé-Violán J, Barcenilla F, Pobo A, Vallés J, Ferri C, Martín-Loeches I, Díaz E, López D, López-Pueyo MJ, Gordo F, del Nogal F, Marqués A, Tormo S, Fuset MP, Pérez F, Bonastre J, Suberviola B, Navas E, León C, GETGAG, Infectious Diseases Work Group (GTEI) of Spanish Society of Intensive and Critical Care Medicine and Coronary Units (SEMICYUC), Infections in Critically Ill Patients Study Group (GEIPC) of Spanish Society of Infectious Diseases and Clinical Microbiology
Medicina intensiva / Sociedad Española de Medicina Intensiva y Unidades Coronarias. 2012 Mar. 103-37. FI: 1.323

Papel dual de las calpaínas en la involución de la glándula mamaria murina tras la lactancia: Implicaciones en el desarrollo tumoral post-gestacional.

Referencia:
BFU2013-46434-P
Investigador principal:
Rosa Zaragozá Colom
Entidad financiadora:
Ministerio de Economía y Competitividad
Duración:
01/01/2014 - 31/12/2016
Presupuesto total:
€96.800

Beneficios del Programa de Soporte para Familiares de pacientes al final de la vida: estudio multicéntrico

Referencia:
PSI2010-19426
Entidad financiadora:
Ministerio de Ciencia e Innovación
Duración:
19/09/2012 - 19/09/2012
Presupuesto total:
€36.300